Slit/Robo Signaling: Inhibition of Directional Leukocyte Migration
نویسندگان
چکیده
Localized inflammation and the associated influx of leukocytes is a hallmark of the pathogenesis of many diseases. The ability to target the recruitment of leukocytes holds vast therapeutic potential in inflammatory diseases where there is excessive cell recruitment due to an overactive immune response, or the improper resolution of the initial response resulting in chronic leukocyte infiltration.
منابع مشابه
Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration.
Slit regulates migration of not only neurons, but also nonneuronal cells, such as leukocytes and cancer cells. Slit effect on cancer cell migration has not been well-characterized. In this study, we used several different assays to examine Slit effect on breast cancer cell migration in vitro. We show that ubiquitin-specific protease 33 (USP33)/VDU1, originally identified as a von Hippel-Lindau ...
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